Effect of Synbiotic on the Treatment of Jaundice in Full Term Neonates: A Randomized Clinical Trial / 대한소아소화기영양학회지

PURPOSE: Jaundice accounts for most hospital admissions in the neonatal period. Nowadays, in addition to phototherapy, other auxiliary methods are used to reduce jaundice and the length of hospitalization. This study aimed to investigate the effect of probiotics on the treatment of hyper-bilirubinemia in full-term neonates. METHODS: In this randomized clinical trial, 83 full-term neonates, who were admitted to the hospital to receive phototherapy in the first 6 months of 2015, were randomly divided into two groups: synbiotic (SG, n=40) and control (CG, n=43). Both groups received phototherapy but the SG also received 5 drops/day of synbiotics. Serum bilirubin, urine, stool, feeding frequency, and weight were measured daily until hospital discharge. A p-value<0.05 was considered statistically significant. RESULTS: The mean total serum bilirubin in the SG was lower than that in the CG (9.38±2.37 and 11.17±2.60 mg/dL, respectively). The urine and stool frequency in the SG was significantly higher than that in the CG (p<0.05). The duration of hospitalization in the SG was shorter than that in the CG. CONCLUSION: Use of synbiotics as an adjuvant therapy had a significant treatment effect on jaundice in full-term neonates. Further studies including larger samples with long follow-up periods are essential to confirm the benefits of routine use of synbiotics in neonatal patients with jaundice.

Demographic features and high prevalence of celiac disease in patients with irritable bowel syndrome in Khoram Abad, Lorestan

Background: many patients with irritable bowel syndrome [IBS] may have undiagnosed celiac disease [CD]. Diagnosis of CD is important because early diagnosis can prevent serious complications. The purpose of this study was to investigate the demographic features and prevalence of CD in patients with IBS in Khoram Abad, Lorestan

Materials and Methods: this descriptive cross-sectional study was conducted on 369 patients with IBS who were diagnosed based on Rome III criteria and attended to gastrointestinal clinic of Shohada-y-Ashayer Hospital in KhorramAbad from June 2015 until March 2016. 31 patients did not accept to participate so were excluded from the study. Serological tests were performed and seropositive cases were underwent upper gastrointestinal endoscopy and duodenal biopsy. Data were analyzed using descriptive statistics, t test and Chi-square test through SPSS software version 22

Results: the mean age of the patients with CD was 31+/-12 years and most of them [72.7%] were women. Most of CDs were diarrheal dominant IBS [77.3%]. Among 338 patients who completed the study, 25 patients [7.4%] were seropositive, and CD was confirmed in 22 of them [6.5%] according to the Marsh classification. Marsh I was reported in seven cases, Marsh II in four, and Marsh III in 11 cases

Conclusion: considering the high prevalence of CD [6.5%] in patients with IBS, the overlap of the symptoms, as well as the importance of timely diagnosis of CD, it is suggested to screen CD in patients with IBS